Ina Sevic 1, Fiorella Mercedes Spinelli 1, Daiana Lujan Vitale 1, Antonella Icardi 1, Lucia Romano 2, Alejandra Brandone 3, Paula Giannoni 4, Carolina Cristina 2, Marcela Fabiana Bolontrade 5 and Laura Alaniz 1
In this work, we compared mRNA levels of Hyaluronan (HA) metabolism members and BRCA genes, known to be involved in the tumoral process, between tumor and non-tumor adjacent tissue and its correlation with previously proposed biomarkers (ER, PR, HER2 and KI67) in order to assess their value as a progression biomarkers. We show alteration in HA metabolism in colorectal but not breast cancer. However, we found a decrease in Hyaluronidase 1 HYAL1 levels in the breast but not colorectal cancer. We also show lower HA levels in tumor compared with normal tissue that could indicate a possible influence of tumor on its surrounding “normal” tissue. In both breast and colorectal cancer, CD44 and BRCA2 showed a strong positive correlation. Besides, our results show first indicators that qPCR of the analyzed genes could be used as an easy and low-cost procedure for the evaluation of molecular markers we propose here
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