Huyen Cao
Background: Remdesivir is an antiviral drug that has been used to treat hospitalized COVID-19 patients. The efficacy of Remdesivir in this patient population is currently under debate. We conducted a systematic review and meta-analysis to evaluate the efficacy of Remdesivir in hospitalized patients with COVID-19.
Methods: We searched multiple databases for randomized controlled trials, observational studies, and case series that reported Remdesivir's efficacy in hospitalized COVID-19 patients. We included studies that reported on clinical improvement, time to recovery, mortality rate, and adverse events. We conducted a meta-analysis of the included studies using a random-effects model. We assessed the risk of bias and quality of evidence using the Cochrane Risk of Bias tool and GRADE guidelines, respectively.
Results: We included 25 studies with a total of 9,063 hospitalized COVID-19 patients. The meta-analysis showed that Remdesivir was associated with a significant reduction in time to clinical improvement (mean difference: -1.15 days, 95% CI: -1.82 to -0.49) and an increased proportion of patients achieving clinical recovery (OR: 1.61, 95% CI: 1.29 to 2.01). Remdesivir was also associated with a decreased risk of mortality (OR: 0.68, 95% CI: 0.55 to 0.85). However, there was considerable heterogeneity among the included studies, and the quality of evidence was moderate to low.
Conclusion: Our systematic review and meta-analysis suggest that Remdesivir may be effective in reducing time to clinical improvement, increasing the proportion of patients achieving clinical recovery, and decreasing the risk of mortality in hospitalized COVID-19 patients. However, the quality of evidence is moderate to low, and further research is needed to clarify the optimal dosing, duration of treatment, and potential adverse effects.
Comparte este artículo
English 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi 