Revista de nefrología y terapéutica

Impact of Immunosuppressive Therapy on Renal Transplant Outcomes: A Meta-analysis

Abstract

Zuzanna Rudzki

Renal transplantation is the treatment of choice for End-Stage Renal Disease, offering improved survival and quality of life compared to dialysis. However, the success of renal transplantation is heavily dependent on the effective management of immunosuppression to prevent graft rejection while minimizing adverse effects. This meta-analysis examines the impact of various immunosuppressive therapies on renal transplant outcomes, including graft survival, patient survival, acute rejection rates, and long-term complications. By analyzing data from multiple randomized controlled trials and cohort studies, we aim to provide a comprehensive overview of the efficacy and safety profiles of different immunosuppressive regimens. Our findings suggest that while newer immunosuppressive agents have improved graft survival rates, they are associated with an increased risk of infection and malignancy. This study highlights the need for personalized immunosuppressive strategies to optimize transplant outcomes while minimizing risks