Medicina molecular y genética

Determination of the Effectiveness of Chlorine Dioxide in the Treatment of COVID-19

Abstract

Insignares-Carrione Eduardo, Bolano Gomez Blanca, Andrade Yohanny, Callisperis Patricia, Suxo Ana Maria, Arturo Bernardo Ajata San Martin and Camila Ostria Gonzales

Introduction: The aim of this review is to determine the Effectiveness of Oral Chlorine Dioxide in the Treatment of COVID-19.

Methods: Research on the mechanism of action of chlorine dioxide on viruses, on the oral consumption of water-solubilized ClO₂ and on its toxicity was reviewed; a quasi-experimental investigation was conducted on the use of oral water-soluble chlorine dioxide in the treatment of 20 patients with active COVID-19 infection, compared to a control group of 20 patients not treated with chlorine dioxide.

Results: To compare the effect in the experimental group versus the control group, a paired test was performed using the Wilcoxon-Mann-Whitney test (α: 95%). Within the experimental group, a significant difference was observed in all general symptoms when comparing day 0 to day 07. Some even disappeared after day 7. Those values that did not disappear completely on day 7 did not differ from those on days 14 and 21 (p>0.05). As for headache, it decreased very significantly (p<0.0001) from day 0 with respect to subsequent days. When comparing the experimental group with the control group on the seventh day post manifestation of symptoms, a significant difference was found in the experimental group with respect to the control group for the symptoms Fever (p: 0000), Cough (p: 0.0001), Chills (p: 0.0015) and Dyspnea (p: 0.0047). When performing the visual analogous comparison of pain in the control group and in the experimental group, it was found that in all the items that make up the scale decreased significantly in this group with respect to the Control group. On day 14 post manifestation the difference was greater (p<0.001). When evaluating both groups (Control and Experimental) in the laboratories, a difference was found for the values for the parameters PC Reactive (p: 0.0398) and DH Lactate (0.0422), with higher scores for the experimental group; no difference was found in the rest of the parameters. The results in general (p<0.05) demonstrate the hypothesis that chlorine dioxide is effective in the treatment of COVID-19. It was found that in all the items that make up the scale decreased significantly in this group with respect to the Control group. On day 14 post manifestation the difference was greater (p<0.001).

Discussion: When evaluating both groups (Control and Experimental) in the laboratories, a difference was found for the values for the parameters PC Reactive (p: 0.0398) and DH Lactate (0.0422), with higher scores for the experimental group; no difference was found in the rest of the parameters. The results in general (p<0.05) demonstrate the hypothesis that chlorine dioxide is effective in the treatment of COVID-19. It was found that in all the items that make up the scale decreased significantly in this group with respect to the Control group. On day 14 post manifestation the difference was greater (p<0.001). When evaluating both groups (Control and Experimental) in the laboratories, a difference was found for the values for the parameters PC Reactive (p: 0.0398) and DH Lactate (0.0422), with higher scores for the experimental group; no difference was found in the rest of the parameters. The results in general (p<0.05) demonstrate the hypothesis that chlorine dioxide is effective in the treatment of COVID-19. a difference was found for the values for the parameters PC Reactive (p: 0.0398) and DH Lactate (0.0422), with higher scores for the experimental group; no difference was found in the rest of the parameters. The results in general (p<0.05) demonstrate the hypothesis that chlorine dioxide is effective in the treatment of COVID-19. A difference was found for the values for the parameters PC Reactive (p: 0.0398) and DH Lactate (0.0422), with higher scores for the experimental group; no difference was found in the rest of the parameters. The results in general (p<0.05) demonstrate the hypothesis that chlorine dioxide is effective in the treatment of COVID-19.

Conclusion: Chlorine dioxide is effective in the treatment of COVID-19 and the mechanisms of action by which it acts to achieve it are proposed in this work. We recommend doing more research. We recommend conducting double-blind studies and delving into studies of toxicological safety and therapeutic efficacy of chlorine dioxide in pathologies of epidemiological impact in the near future.