Revista de medicina deportiva y estudios de dopaje

Unravelling the Effects of Indomethacin on Steroid Metabolism: Implications for Endocrine Disruption and Urinary Steroid Profiling in Anti-Doping Analyses

Abstract

Sara Baglio*

Indomethacin, a commonly used non-steroidal anti-inflammatory drug, has been shown to potentially impact steroid metabolism, leading to implications for endocrine disruption and urinary steroid profiling in anti-doping analyses. This abstract presents a summary of the effects of indomethacin on steroid metabolism and its broader implications. Studies investigating the influence of indomethacin on steroid-metabolizing enzymes have demonstrated alterations in enzymatic activity, which can disrupt the normal balance of steroid hormones in the body. Consequently, these disruptions can have implications for urinary steroid profiling, potentially leading to false-positive or false-negative results in anti-doping testing. Understanding the effects of indomethacin on steroid metabolism is crucial for accurate interpretation of urinary steroid profiles in antidoping analyses and for identifying potential endocrine disruption in individuals using the medication. Further research is needed to investigate the underlying mechanisms and long-term consequences of indomethacin-induced effects on steroid metabolism and to develop strategies to mitigate the confounding effects of indomethacin in anti-doping analyses.