Revista de diagnóstico y biomarcadores moleculares

Association of Adiponectin Gene Functional Polymorphisms (+45T/G and 276G/T) with Obese Breast Cancer

Abstract

Mohan Reddy N, Kalyana Kumar CH and Kaiser Jamil

Adiponectin is a naturally occurring, active protein produced by white adipose tissue circulating levels of which have been associated with breast cancer risk. The ADIPOQ +45T/G and 276G/T polymorphisms are likely to play an important role in the susceptibility to breast cancer. To evaluate the prevalence of polymorphism of Adiponectin gene a case-control study was performed in 154 breast cancer patients and 142 controls in South India. We utilized PCR- RFLP based assay to evaluate the association between the +45T/G and 276G/T polymorphism of the ADIPOQ gene and breast cancer risk in a case control study. Frequencies of ADIPOQ +45T/G were 74%, 24% and 2% in the breast cancer patients and 83%, 15% and 2% in the controls, respectively. ADIPOQ +45T/G genotype showed a 1.7- fold increased risk for breast cancer and the 276G/T genotype showed a 1.6-fold increased risk for breast cancer. In the compound genotypes, T45G//G276T and T45G/T276T showed a 1.668 and a 1.791-fold increased risk for breast cancer. Our findings suggest that the ADIPOQ +45T/G and 276G/T polymorphism may be a useful biomarker associated with the risk of breast cancer in obese women in Indian population