Revista de genética e investigación del ADN.

The Impact of Genetic Variation on Drug Response and Personalized Medicine

Abstract

Li Wei*

The impact of genetic variation on drug response is a critical aspect of personalized medicine, aiming to optimize therapeutic outcomes by tailoring treatment regimens to individual genetic profiles. Genetic variability in drug-metabolizing enzymes, drug transporters and drug targets can significantly influence pharmacokinetics and pharmacodynamics, leading to inter-individual variability in drug efficacy, toxicity and adverse reactions. This mini-review provides an overview of the role of genetic variation in drug response and its implications for personalized medicine. We discuss key genetic determinants of drug response, approaches for pharmacogenomic testing, challenges in implementation and future perspectives for integrating genetic information into clinical practice.