Revista de genética e investigación del ADN.

Mining the Unknown: Assigning Function to Noncoding SNPs

Abstract

Cm Skevaki*

The eyes, kidneys and cardiovascular system are among the tissues and organs affected by diabetes, a chronic metabolic disorder. The prevalence of diabetes in the world is 8.8 percent, with approximately 90 percent of cases being type 2 diabetes, according to the World Health Organization. In the early stages of diabetes, there are no significant clinical signs or symptoms. As a result, screening can be a useful tool for reducing diabetic complications. The Middle East's health care system has been burdened with exorbitant costs as a result of the alarming rise in diabetes prevalence over the past few decades. We investigated the role of single-nucleotide polymorphisms (SNPs) in the pathogenesis of diabetes in the Middle Eastern population because genetic changes are one of the major risk factors associated with diabetes predisposition. We evaluated the Middle Eastern population's molecular pathology of diabetes in this review, paving the way for the introduction of an effective SNP-based diagnostic panel for diabetes screening. Since there are 370 million people living in the Middle East; The current review may serve as a useful model for the implementation of SNP-based diagnostic panels in additional populations and nations.