Revista de medicina y complicaciones diabéticas

Genetic Risk Factors for Diabetic Peripheral Neuropathy: A Systematic Review

Abstract

Syed Shah Zaman Haider Naqvi and Yong Xu

Diabetic peripheral neuropathy (generally called DPN) is the leading cause of neuropathy worldwide. It brings enormous morbidity, affects quality of life and escalates mortality. While genetic factors in the pathogenesis of diabetes are studied extensively, limited literature is available on impact of genetic variants in the development of diabetic peripheral neuropathy which might represent tip of an iceberg. The objective of this article is to comprehensively review the genetic risk factors for diabetic peripheral neuropathy which will help physicians better assess the risk, make preventative measures and tailor the treatment in genetically susceptible individuals.