Revista de Anestesiología Clínica: Acceso Abierto

Enantiomeric Excess of Bupivacaine (S75:R25): Laboratory Study, Clinical Application and Toxicity

Abstract

Luiz Eduardo Imbelloni

Local anesthetics are drugs that produce temporary and localized blockage of nerve conduction. Depending on the place of administration and the dose used, they can lead to interruption of sensitivity, autonomous innervation and motricity, and must associate properties that, in addition to efficacy, ensure safety.

Most pharmaceutical drugs are released in racemic form. The study of the chirality of substances is an important field in the pharmaceutical industry and agrochemicals. Several review articles on chirality have been published, but none of them address the presence of an enantiomeric excess. In Brazil, an enantiomeric excess local anesthetic containing 75% of the S-enantiomer and 25% of the R-enantiomer was investigated, and later approved for use in regional anesthesia.