Biología molecular: acceso abierto

Molecular Biology and Genetics Disease

Abstract

P. Minor*

Alzheimer's disease is a progressive neurodegenerative disorder that affects millions of people worldwide. The disease is characterized by the accumulation of amyloid-beta plaques and neurofibrillary tangles in the brain, which lead to the loss of neurons and cognitive decline. While the exact causes of Alzheimer's disease are not fully understood, recent research has shed light on the molecular biology and genetics underlying the disease. One of the key molecular features of Alzheimer's disease is the accumulation of plaques in the brain. Peptide that is produced through the cleavage of the amyloid precursor protein by the enzymes. In healthy individuals, brain through a variety of mechanisms, including enzymatic degradation and clearance by immune cells. However, in Alzheimer's disease, accumulates in the brain, forming plaques that are toxic to neurons.