Revista de citología e histología

Subsets of Regulatory T Cells in Sarcoidosis Patients

Abstract

Piotr Yablonskiy*

Many researchers have recently backed the autoimmune theory of sarcoidosis. The presence of an uncontrolled inflammatory response at the local and systemic levels in sarcoidosis patients did not rule out the possibility that immunoregulatory mechanisms were compromised. The purpose of this study was to assess the distribution and disturbance of circulating Treg cell subsets in the peripheral blood of sarcoidosis patients. Materials and procedures: In 2016-2018, a prospective comparative study was conducted. The diagnosis of pulmonary sarcoidosis was made using standard criteria. For Treg immunophenotyping, we used two ten-color antibody combinations.