Revista de bioingeniería y ciencia biomédica

Studying Human Hair Follicles through Animal Models and Other Methods

Abstract

Ellis Sono

Understanding human hair follicle biology is crucial for developing treatments for hair disorders and promoting hair regrowth. This study explores various approaches, including animal models and other methods, for studying human hair follicles. Animal models such as mice, rats and pigs have been extensively utilized due to their genetic tractability, physiological similarities and feasibility for experimental manipulation. These models offer insights into hair follicle development, cycling and regeneration, as well as the pathogenesis of hair disorders. Additionally, in vitro models using human hair follicle organ culture, 3D skin equivalents and tissue engineering techniques provide valuable tools for investigating hair follicle biology and evaluating therapeutic interventions. Furthermore, advances in imaging modalities, molecular profiling and omics technologies have enabled comprehensive characterization of human hair follicles at the cellular and molecular levels. Integration of these approaches facilitates a deeper understanding of hair follicle biology and the development of novel therapies for hair-related conditions.