Revista de filogenética y biología evolutiva

Study of Conserved Domain across Divergent Phylogenetic Lineages of Long Neurotoxin from Genus Naja (Elapidae Family)

Abstract

Sherkhane AS , Waghmare Somnath and Gomase VS

Naja are a toxic genus of Elapids family in the old world. Long neurotoxins are mixtures of peptides, enzymes that interfere with the normal function of the nervous system and potently block α7 homo-oligomeric neuronal AChRs causing paralysis. The aim of the present study is to identify the origin of long neurotoxin, multiple sequences analysis for prediction of structure and function of neurotoxin and observing the conserved pattern of amino acid residues and to construct the phylogenetic tree for organizing evolutionary history of Naja genus from Elapidae family.