Alsayed Ali Mahran, Husam Eldien H. Osman, Ahmed M. A. Abd El-Mawla and Adel M. Attia
The protective effect of zinc (Zn) on the liver and kidney of albino rats exposed to intraperitoneal injection of cadmium chloride (CdCl2) was studied. Light microscopic examination for rats which were injected intraperitonealy with of 0.16 mg CdCl2/kg of body weight for 8 weeks indicated severe histological changes in both liver and kidney. In liver, a blurred trabecular structure, vacuolar degeneration and increased density of nuclear chromatin with very compact nuclear structure were found in hepatocytes. Moreover; mononuclear cell infiltrations and necrosis of single cells were also observed. In the kidney tubules, degeneration and hypertrophy of epithelial cells and dilation in the glomeruli were also observed. The effects of cadmium on the ultrastructures of both organs were studied. There are ultrastructural damages appeared in both organs as nuclear membrane damage, chromatin condensation, swelling of the mitochondria with regression of mitochondrial cristae, degranulation and disintegration of protein-synthesizing structures such as rough endoplasmic reticulum, increased number of lysosomes and ultimately cell death. Zn partially alleviated the damage observed in both the liver and kidney and differences in histological structure has been observed between the Zn-Cd and the control groups. Our results demonstrate the protective effect of ZnCl2 in prevention CdCl2- induced significant toxic pathological changes in the liver and kidney of the albino rats.
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