Revista de Ciencias Químicas

Plant Derived Compounds Having Activity against P388 and L1210 Leukemia Cells

Abstract

JR Patel, B Choubisa, BZ Dholakiya

Cancer is a major cause of death and the number of new cases as well as the number of individuals living with cancer is expanding continuously. Due to the enormous propensity of plants that synthesize mixture of structurally derived bioactive compounds, the plant kingdom is potentially diverse source of chemical constituents with murine leukemia activity. Plant derived compounds have played an important role in the development of several clinically useful anticancer agents having activity against murine leukemia. These include vinca alkaloids, lignans, terpenoids, quinines and phytochemicals such as flavones, flavonoids, flavonol. The active compounds which have been isolated from various plant sources are listed, classified and discussed in terms of their activity against murine leukemia cells. Structure-activity relationship has been studied for further development of compounds which show activity against leukemia cells.