Revista de bioanálisis y biomedicina

Molecular-Genetic Polymorphisms of Dopamine, Serotonin and Androgenic Systems as Molecular Markers of Success in Judo Wrestling Sportsmen

Abstract

Polina R Butovskaya, Marina L Butovskaya, Vasiliy A Vasilyev, Oleg E Lazebny, Dmitri V Shibalev, Elizaveta V Veselovskaya, Irina G Udina and Alexey P Ryskov

In this study we tested gene-candidates, associated with the stress-resistance and personality traits, aggression in particular, in 16 world-class judo sportsmen, and 40 young men as a control sample from general Russian population (all men were of Caucasian origin). The polygenic profile with 9 candidate genes which included 10 polymorphisms (i.e., AR, DRD4, DRD2, DAT1, COMT, 5-HTTL, MAOA, HTR1A and HTR2A) connected to the functioning of serotonin, dopamine, and androgenic systems were determined. It was demonstrated that judo sportsmen significantly differed from the control group by higher frequencies of AR alleles with lower numbers of CAG repeats, V/V genotype of COMT gene, and G/G genotype of HTR1A gene, thus suggesting these polymorphisms as genetic markers of sportive success in wrestling.