Revista de investigación traslacional en oncología

Modulation of the ROCK/Akt/eNOS pathway by simvastatin protects against 5-fluorouracil cardiotoxicity

Abstract

Radwa Nasser Muhammad

5-Fluorouracil (5-FU) is a highly effective anticancer drug, widely incorporated in the management of different solid tumours, and is a cornerstone therapy in colorectal cancer. Its use is associated with a wide range of different toxicities, including several reports of fatal cardiotoxicity which was first reported four decades ago. Since then, only some efforts were done to understand the pathophysiology and molecular mechanisms associated with this type of toxicity, moreover; there is no effective preventive measure against this toxic effect. Until now, myocardial ischemia due to coronary vasospasm is the most accepted theory.