Revista de bioingeniería y ciencia biomédica

Mass Spectrometery as an Analytical Method for Determining Protein Structures

Abstract

Aaliya Shah, Farhana Ahad, Medha Priyadarshini, Mosin Saleem Khan and Syed Mudassar

Mass spectrometry (MS) has become a powerful technology in the discovery and development of protein therapeutics in the biopharmaceutical industry. This review article describes the two main types of mass spectrometry methods for determining the protein structure. Further the role of tandem mass spectrometry in diagnostics has also been highlighted. Mass spectrometry based proteomics is a central life science technology that has realized great progress towards identification, quantification and characterization of the proteins that constitute a proteome.