Depresión clínica

Biocompatible amifostine nanoemulsion via expression of nephrin in nephrotoxic experimental rat

Abstract

Nadia Mohamed Ahmed Mohamed

Drug-induced kidney injury is the causative of acute kidney failure. Amifostine loaded silica nanoemulsion was synthesized using water/oil emulsion with the help of ultra-sonication waves. The nanoemulsion was prepared using Tetraethyl Orthosilicate [TEOS], Cetyltrimethylammonium Bromide [CTAB], Castor Oil [CAO] and Amifostine [AMF] as a source for silica, surfactant, extra stabilizing agent and a model drug respectively. The as synthesized nanoemulsion of silica and silica loaded with amifostine [SiNPs@AMF] was examined via Transmission Electron Microscopy [TEM] and Dynamic Light Scattering [DLS] in terms of particles shape and hydrodynamic average size.