Revista de citología e histología

Arsenic-induced Histological Alterations in Various Organs of Mice

Abstract

Abu Shadat Mohammod Noman, Sayada Dilruba, Nayan Chandra Mohanto, Lutfur Rahman, Zohora Khatun, Wahiduzzaman Riad, Abdullah Al Mamun, Shahnur Alam, Sharmin Aktar, Srikanta Chowdhury, Zahangir Alam Saud, Zillur Rahman, Khaled Hossain and Azizul Haque

Deposition of arsenic in mice through groundwater is well documented but little is known about the histological changes of organs by the metalloid. Present study was designed to evaluate arsenic-induced histological alterations in kidney, liver, thoracic artery and brain of mice which are not well documented yet. Swiss albino male mice were divided into 2 groups and treated as follows: Group 1: control, 2: arsenic (sodium arsenite at 10 mg/kg b.w. orally for 8 wks). Group 2 showed marked degenerative changes in kidney, liver, thoracic artery, and brain whereas Group 1 did not reveal any abnormalities on histopathology. We therefore concluded that arsenic induces histological alterations in the tested organs.