Depresión clínica

Adult Mice Chronically Exposed to THC during Adolescence do Not Change Their Anxiety-Like Behaviours Due to Impaired Ghrelin Signaling

Abstract

Shanabrough Rania

Understanding the long-term impacts of marijuana usage is essential as adolescent marijuana use has been rising. According to earlier studies, marijuana use during adolescence raises the likelihood of mental disorders such schizophrenia, depression, and anxiety. The peptide ghrelin, which is largely generated in the gut, has a significant role in feeding behaviour. Recent research has demonstrated that ghrelin and the growth hormone secretagogue receptor, which is its receptor, are critical mediators of stress, anxiety, and depressive-like behaviours in animal models. Here, we examined the effects of persistent administration on anxiety-like behaviours in knockout mice and their wild-type littermates during late adolescence. Continuous exposure during late adolescence, according to our findings.