Revista de genética y genomas.

Understanding Genetic Diversity of Human Cytomegalovirus (HCMV), Drug Resistance Testing and the Prevalence of Resistance Mutations

Abstract

Camilla Debette

Human Cytomegalovirus (HCMV) is a widespread herpesvirus that infects a large portion of the human population worldwide. Despite often remaining asymptomatic in healthy individuals, it poses significant risks to immunocompromised individuals such as transplant recipients, HIV/ AIDS patients, and unborn babies when contracted during pregnancy. The emergence of drug-resistant strains of HCMV presents a growing concern in clinical management, emphasizing the importance of understanding its genetic diversity and the prevalence of resistance mutations. This article explores the genetic diversity of HCMV, methodologies for drug resistance testing, and the prevalence of resistance mutations.