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Synthesis of 2,6-Diaryl-4-Indolylpyridines as Novel 5-LOX Inhibitors

Abstract

Berihu Tekluu, Sunanda Kumari Kadiri and Siddaiah Vidavalur

A series of 2,6-diaryl substituted -4-indolylpyridines have been synthesized from indole-3-carboxaldehyde and acetophenones and all the compounds characterized by spectroscopic techniques. 5-Lipoxygenase enzyme inhibitory activities were performed for all the compounds. Among the 2, 6-diaryl substituted -4-indolylpyridine derivatives 3ad and 3aa showed good activity.

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