Jyoti Rani, Monika Saini, Sanjiv Kumar and Prabhakar Kumar Verma
A series of 5-(substituted aldehyde)-2-imino-7-methyl-3-oxo-N-phenyl-1,2,3,5-tetrahydroimidazo [1,2-a]pyrimidine-6-carboxamide derivatives was synthesized and their chemical structures were confirmed by 1H-NMR, FT-IR and elemental analysis studies. The synthesized derivatives were evaluated for their in vitro antimicrobial potential and validated by UV visible spectroscopy at absorbance 272 nm and comparable with lamivudine as standard. These compounds validated as per International Conference on Harmonization (ICH) guideline in the range of 2-20 μg/ml. Validation study indicated that, compounds 1, 2 and 3 exhibited good percentage purity at absorbance 272 nm and there is no interference of diluents at 272 nm. Antimicrobial results indicated that compound 2 was found to be most active against microbial species (bacterial and fungal).
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