Química medicinal

Review on Anti−Cancer Potential of Novel Imidazothiazoles and their Synthetic Methods

Abstract

Vajid Parasuraman Kunnath1*, Shadiya Chediyan Kandy2 and Akash Marathakam3

In recent studies on cancer treatment, researchers find out that several enzymatic mutations lead to the development of cancerous cells. Such as Indoleamine 2,3-dioxygenase 1 (IDO1), B-Raf kinase, and ErB4 (HER4) kinase inhibitors. Imidazothiazole-based derivatives are gained more attention among scientists due to their wide variety of pharmacological activities, such as anti-fungal, anti-bacterial, anthelmintic, and anti-cancer activities as well as ease of synthesis of these compounds. During the search for compounds that can act as anti-neoplastic agents through inhibition of these enzymatic receptors, researchers found that imidazothiazole-based compounds and their derivatives show more potent anticancer activity. In this review, we focus on some traditional synthetic methods proposed by researchers to prepare imidazothiazole derivatives and their anticancer potential along with docking studies and cell line studies. Which will help researchers to develop their studies through imidazothiazole derivatives.