Química medicinal

Recent Advances in Natural Product-Based NF-κB Inhibitors as Anticancer and Anti-Inflammatory Agents

Abstract

Arijit Nandi and Anwesha Das

Certain activation of signaling pathways plays a great role in cancer pathogenesis and the growth and progression of the tumor cells. Among the several signaling pathways intensively entangled in cancer progression, NFâ??κB is one of the important pathways which are actively explored by researchers [1]. This B cell-specific transcription factor NFâ??κB family is first discovered by David Baltimore’s group. It contains five different DNAbinding proteins which are actively involved in the formation of homodimers and heterodimers. NFâ??κB proteins are key regulators of innate and adaptive immune responses that can accelerate cell proliferation, inhibit apoptosis, promote cell migration and invasion, and stimulate angiogenesis and metastasis [2]. The normal activation of the NFâ??κB is necessary for the survival of the cells and immunity, its deregulation can results development of cancer and multiple inflammatory diseases. Therefore NFâ??κB is one of the major targets of anticancer and anti-inflammatory molecule development.