Manta S, Dimopoulou A, Kollatos N, Kyrkou G, Spanos S and Komiotis D
Nucleosides take an important place in medicinal chemistry as the structural basis for the development of therapeutic agents. The chemistry of substituted base-modified nucleosides has been an interesting field of study over the last two decades owing to their biological properties. This mini-review summarizes recent efforts on the synthesis of C5- and C8-alkynyl base-modified pyranonucleoside analogues using Sonogashira cross-coupling reaction under microwave irradiation.
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