Revista de SIDA e investigación clínica

Prevalence of Viral Coinfections with EBV and CMV and Its Correlation with CD4 Count In HIV-1 Serpositive Patients

Abstract

Deepali Patekar, Supriya Kheur, Pravin More, Chaitrali Hambire and Mohit Kheur

Objectives: The objective of this study is to estimate the level of antibodies to EBV and Human Cytomegalovirus (HCMV) in peripheral blood in seropositive HIV-1 patients and its correlation with CD4 cell count and clinical and demographical details.

Materials and Methods: 60 patients who are HIV-1 seropositive were included in the study, with 30 seronegative patients as control group. After proper written consent, thorough oral examination was done and CD4 cell count of the patient was noted. Serological assessment of antibodies against EBV & CMV was done as an indicator for viral coinfection in these patients.

Results: There was a significant increase in the antibody titer against EBV & CMV in the patients with CD4 count less than 200 as compared to HIV-1 seropositive patients with CD4 count more than 200. The oral manifestations were seen more prominently in direct correlation with CD4 count of the patients.

Conclusion: There was a higher titre of EBV-1 and CMV antibodies in HIV-1 seropositive patients. A correlation between antibodies to CMV and CD4 count is seen in our population, with 86.4% of patients presenting with oral manifestations.