Revista de SIDA e investigación clínica

Predictors of Pulse Rate and Time to First Recovery among Diabetes Mellitus Patients under Treatment; Application of Joint Model

Abstract

Awoke Seyoum Tegegne and Chalachew Agimass

Background: The main objective of this study was to investigate joint predictors of pulse rate and time to first recovery among diabetes mellitus patients under treatment.

Method: A retrospective cohort study design was conducted in this study. Linear mixed model and cox-proportional hazard model for separate analysis and joint model for the two responses were used.

Results: Among the participants, 66.7% of patients were female, and 19% of the patients had a family disease history. The time needed to reach the first recovery among male patients was significantly longer compared to female patients. The time needed to reach the first recovery among patients with no other related disease was significantly shorter as compared with patients with other related diseases (HR=0.0893).The estimated association parameter (α) in the joint model was -1.5108, with a p-value<0.001. The result indicates that the higher the pulse rate was associated with the lower time to the first recovery.

Conclusion: The variable age, residence area, other related diseases, and hypertension significantly and jointly affected both of the two responses. Due attention should be given to aged patients, patients with family disease history, patients with other related diseases, and rural patients.