Química medicinal

Polarographic Study of Meta-Hydroxyacetanilide and its Determination

Abstract

Swaroopa Rani N Gupta

Present paper deals with polarographic study of effect of maxima suppressors and supporting electrolytes on anodic waves of meta-hydroxyacetanilide and polarographic determination of meta-hydroxyacetanilide under optimum concentration of maxima suppressors and supporting electrolytes. The polarographic method has been developed to study qualitatively the effect of maxima suppressor (fuchsin) and supporting electrolyte (nitric acid) on oxidation wave of meta-hydroxyacetanilide. Polarograms of system were recorded between 500 to 1300 mV by using Rotating Platinum micro Electrode as anode and Saturated Calomel Electrode as cathode on D.C. Recording Polarograph using Omniscribe recorder. It shows a similar behavior to that observed for paracetamol. It produces anodic wave at rotating platinum electrode. The oxidation yields the 3-N-acetylaminosemiquinone and represents a reversible reaction. Polarographically a value of 900 mV is found for decomposition potential of meta-hydroxyacetanilide. Wave analysis point to 1-electron step for each wave. Waves of meta-hydroxyacetanilide are only proportional to concentration at low concentrations.