Revista de SIDA e investigación clínica

Oxidative Stress Parameters in Women with HIV and HIV/hepatitis B and/or C Co-infection

Abstract

Lubov I Kolesnikova, Sergey I Kolesnikov, Marina Darenskaya, Lyudmila Grebenkina, Elena Timofeeva, Olga Leshenko, Natalya Semenova, Nadejda Kurashova and Olga Vanteeva

The pathogenesis of HIV/hepatitis B and/or C co-infection is far from being understood; yet, some studies have shown its relationship with oxidative stress. Because of oxidative stress (conjugated dienes and thiobarbituric acid reactants) and antioxidant defense systems (superoxide dismutase activity, α-tocopherol, reduced and oxidized glutathione) had different parameters in 26 women with HIV-monoinfection and 27 women with HIV/hepatitis B and/or C co-infection (with no signs of AIDS), they were evaluated. Spectral fluorofotometric methods were used. Statistical analysis was performed by parametric and non-parametric methods. The evaluation found that while conjugated dienes levels were significantly higher, superoxide dismutase (SOD) activity and α-tocopherol levels were significantly lower in women with HIV/hepatitis B and/or C co-infection than in those with HIV-monoinfection. Concurrently, during the highly active antiretroviral therapy (HAART), conjugated dienes, thiobarbituric acid reactants mean levels were lower; SOD activity and α-tocopherol levels were higher in HIV-monoinfected patients than in those with HIV/hepatitis B and/or C co-infection (with no signs of AIDS). This outcome was characterized by more expressed oxidative stress.