Revista de SIDA e investigación clínica

Menstrual and Reproductive Function in Women with HIV-infection and Antioxidant Vitamins Deficiency

Abstract

Lubov I Kolesnikova, Sergey I Kolesnikov, Marina A Darenskaya, Lyudmila A Grebenkina, Elena Timofeeva, Olga Ya Leshenko and Olga Vanteeva

Reproductive age women proportion with HIV-infection increasing, but relationship of antioxidant deficiency and reproductive disorders in this category of patients remain unclear. Objective: To identify antioxidant vitamins deficiency and frequency of reproductive disorders interrelations in women with HIV-infection. 53 women of reproductive age with HIV-infection were divided for 4 groups according to blood serum vitamins concentration: 36 women - α-tocopherol level less than 12 μmol/L; 17 women - α-tocopherol level in the range 12-24 μmol/L; 35 women with retinol level less than 1.05 μmol/L and 18 women - retinol level in the range 1.05-2.8 μmol/L. Spectral fluorofotometric methods were used. Statistical analysis was performed by parametric and non-parametric methods High incidence of menstrual disorders (63%), infertility (36.1%), and luteal phase deficiency was found in the group
of women with HIV-infection and α-tocopherol deficiency. Elevated levels of primary lipid peroxidation (LP) products- diene conjugates, with the absence of significant differences in the content of the thiobarbituric acid reactants in this group were registered. The results obtained showed a close relationship of α-tocopherol deficiency and disorders of the reproductive system in women with HIV-infection. It is a significant reason to recommend including of antioxidant drugs in HIV-women patients of complex pathogenetic therapy to regulate adequately their reproductive function and possibly to preserve reproductive ability in these women.