Revista de ciencias e ingeniería de materiales

Low Pressure Plasma Processing of Collagen Membranes for Anti-Cancer Drug Delivery

Abstract

Alibi Baitukha, Iman Al-Dybiat, Azadeh Valinataj-Omran, Jerome Pulpytel, Marc Pocard, Massoud Mirshahi and Farzaneh Arefi-Khonsari

For targeting the cancer cells, a low pressure ICP reactor was utilised to fabricate a drug delivery system. On the surface of biocompatible collagen membranes, thin plasma polymer coatings were deposited to encapsulate an anticancer drug carboplatin and impart different biologically active functionalities. The characteristics of the deposited films were analysed by FTIR and XPS and the overall functionalities were tested by in vitro and in vivo experiments on the cancer cells lines on the cancer nodules respectively. Preliminary results of fabricated drug delivery systems showed the inhibition of cancer cell proliferation in vitro as well as tumour growth in mice models by 2.8 folds in mass compared to the control case