Revista de SIDA e investigación clínica

Incidence, Predictive Factors and Prognosis of Tuberculosis among Patients with HIV Infection in Guadeloupe 1988-2009

Abstract

Narcisse Elenga, Marie-Thérèse Georger-Sow, Thierry Messiaen, Isabelle Lamaurie, Isabelle Favre, Mathieu Nacher and Gilles Beaucaire

Objective: To determine the incidence, risk factors and prognosis for incident tuberculosis during the follow-up of HIV-infected patients in Guadeloupe. Methods: We conducted a retrospective cohort study using STATA version IC 10.0 (College Station, Texas, USA). Results: A single failure Cox proportional hazards model showed that patients with B CDC category (HR=4.50; 95%CI=1.50-13.60; P=0.007) and patients with C CDC category (HR=138.30; 95%CI=62.80-304.90; P=0.000) were at an increased risk of tuberculosis, whereas patients with low median CD4 count at enrolment ( HR=0.50; 95%CI=0.30- 0.84; P=0.009) and patients treated by ART ( HR=0.45; 95%CI=0.34-0.62; P=0.000) were associated with a low risk of tuberculosis. Conclusion: Our data showed a high incidence of tuberculosis and no socio-economic factors related to tuberculosis among HIV-infected patients. These findings help to effectively guide public health interventions.