Enfermedades infecciosas clínicas: acceso abierto

Exploring the Role of Host Genetics in Susceptibility to Infectious Diseases

Abstract

Michel Edouard

In the intricate dance between pathogens and humans, susceptibility to infectious diseases often seems unpredictable. While environmental factors play a significant role, the genetic makeup of the host also plays a crucial part in determining susceptibility. Over the past few decades, significant strides have been made in understanding how host genetics influence vulnerability to infectious diseases, shedding light on both individual and population-level susceptibilities. This exploration has not only deepened our understanding of disease mechanisms but also paved the way for personalized approaches to treatment and prevention. Human susceptibility to infectious diseases is not solely determined by one gene but is rather a complex interplay of multiple genetic factors. Variations in genes encoding various components of the immune system, such as receptors, cytokines and other immune response mediators, can significantly impact an individual's ability to fend off pathogens.