Revista de genética y genomas.

Exosome as a Paracrine Signal for Stem Cells

Abstract

Youjie Yin and Hansong Deng

Exosomes are extracellular membranous vesicles of 30-100 nm in diameter secreted by different types of cells. It’s essential for cell-cell communication and play important roles for stress response and cellular homeostasis during health and disease. In particular, exosomes released by stem cells was shown to facilitate stem cell maintenance, tissue regenerationï¼Å?and delay neurodegeneration and tumorigenesis. This review will therefore briefly discuss the role of exosomes in stem cells and focus on the physiological role of exosome and cross talk between different tissues in organismal level.