Revista de SIDA e investigación clínica

Etravirine Induced Severe Hypersensitivity Reaction and Fulminant Hepatitis: A Case Report and Review of the Literature

Abstract

Linda Nabha, Gayle P. Balba, Carmelita Tuazon and Princy N. Kumar

We report the first published case of etravirine induced hypersensitivity reaction leading to fulminant hepatic failure in a 49-year-old female patient with Human Immunodefi ciency Virus. She presented with a life threatening rash and end stage organ damage requiring intensive care unit supportive care. Liver biopsy supported the diagnosis of drug-induced hypersensitivity. The patient recovered after withdrawal of etravirine and the use of systemic corticosteroids. The authors describe etravirine drug hypersensitivity as a clinically important reaction and that early recognition can improve survival.