Revista de SIDA e investigación clínica

Echocardiographic Findings and Follow-Up in Two HIVAssociated Pulmonary Arterial Hypertension Cases

Abstract

Mircea Bajdechi, Adriana Gurghean, Georgiana-Elena Stoian, Dragos-Cosmin Zaharia, Tudor Constantinescu, Cristina-Elena Micu, Roxana Cernat, Irina Magdanela Dumitru and Sorin Rugina

Pulmonary arterial hypertension associated with HIV infection is a separate entity. The prevalence is up to one thousand times higher than in general population. The mechanisms are multifactorial and incompletely elucidated. Echocardiography can suggest the diagnosis, but the gold standard method of diagnosing pulmonary arterial hypertension is right heart catheterization. We present clinical and paraclinical findings (NYHA, 6MWD, sPAP, RVGLS) and follow-up in two patients living with HIV, who are included in the Romanian National Program of Pulmonary Arterial Hypertension. In patients, the possible thromboembolism or left heart dysfunction were excluded. Each case has its own particularities, but both of them responded to treatment with sildenafil and improved clinical and paraclinical parameters. Mortality is high, usually due to right heart failure and pulmonary arterial hypertension is considered an independent predictor of death in HIV-infected patients. Co-management with both a Pulmonary Hypertension (PH) expert and a HIV expert is recommended.