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Design, Synthesis, and Evaluation of Glycopeptides Containing Glucosamine

Abstract

Guichao Xu, Xiaomin Wang, Meng Zhang, Li Zeng, Hong Li, Pengchao Gao and Jianwei Zhang

In this study, several novel peptidomimetics were designed and synthesized as potential anti-inflammatory agents. Their anti-inflammatory activity was evaluated using a xylene-induced ear edema model assay. Some of the compounds demonstrated inhibitory activity against xylene-induced inflammation similar to the positive control, aspirin.

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