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Design and Synthesis of New Compounds of Phthalazindion and its Anticonvulsant Activity

Abstract

Rezk R. Ayyad, Ahmed M. Mansour and Ehab M. Mostafa

In this work we synthesized 6,7-Dichloro-1,4-(2H,3H) phthalazinedione (I) [1] and its salt (II) which react with different alkylchloroacetates, afforded
compounds III1-6. When reacted, the compound III2 with ammonia and different amines we obtained on IV and V1-7 respectively. The compound
III2 also react with Hydrazine hydrated, result the compound VI, afforded compound (hydrazide) Hydrazied condensed with different aldehydes,
we obtained on compounds VIII1-10. The compounds III1, III2, III3, III4, III5, IV, V1,V2, V3, VI, VII1, VII5, VII6,VII9, VIII1, VIII2, VIII7 and VIII8 tested as
anticonvulsant against phenobarbitone as reference drug. The compounds III1-3, IV, V3, VI, VIII1,2 showed the most activity while the compounds V2,
VII6,9 revealed moderate Introduction, finally compound VII5 was the lowest activity.

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