Hoda I Bahr and Sameh M Farouk
Background: Although the studies of non-steroidal anti-inflammatory drugs-mediated hepatic dysfunctions has been found to be of great interest to several literatures, a little is known about that of lornoxicam and its possible natural antioxidant herbal therapy.
Objective: The present study aimed to delineate whether intramuscular injection with lornoxicam mediated liver oxidative stress and hepatic degeneration or not, with the same line in an attempt to develop new herbal therapy with basil oil and Moringa oleifera to screen their possible curative and hepatoprotecive impacts.
Methods: 28 adult male albino rats were divided into 4 groups; 7 rats per each. Control, lornoxicam-treated group: rats injected intramuscular with lornoxicam at a dose of 1.4 mg/kg/day. Lornoxicam+M. oleifera -treated group: rats daily exposed to co-administration of lornoxicam and aqueous leaves extract of M. oleifera (500 mg/100 gm b.w/day). Lornoxicam+basil oil- treated group: co-administration of lornoxicam and basil oil (3 ml/kg b.w/day). Results: After two weeks of experiment, our findings revealed that Lornoxicam significantly P<0.05 increased serum GPT, GOT and ALP decreased glutathione and antioxidant enzymes, Paraoxonase/arylesterase activity along with elevation in percentage of DNA fragmentation, sialic acid content, butyryl cholinesterase and myeloperoxidase activity. Meanwhile, Basil oil and M. oleifera increased antioxidants activity, decreased DNA fragmentation and down regulate caspase-3 expression. Both herbs showed relative hepatic architectural improvements against lornoxicam induced liver damage.
Conclusion: Overall, this article summarizes recent knowledge on lornoxicam- induced hepatic damage and provides new insights into therapeutic ability of basil oil and M. oleifera leaves.
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