Química medicinal

Characterization of the Murine K14-FynY528F Transgenic SCC Model Provides Novel Therapeutic Insights

Abstract

Michael D Gober and John T Seykora

Cutaneous squamous cell carcinoma (cSCC) is one of the most common human malignancies. The development of mouse models that accurately recapitulate the human condition is crucial for testing novel therapeutic modalities. In this article we discuss the utility of the K14-Fyn-Y528F transgenic mouse as a model for cSCC and actinic keratosis like precursor lesions and its use in testing novel small molecule kinase inhibitorstopically.