Revista de SIDA e investigación clínica

Bones under Siege: Unravelling the Complexities of HIV-associated Bone Disease

Abstract

Nicholas Sebastian

Bones under Siege: Unravelling the Complexities of HIV-Associated Bone Disease" delves into the intricate relationship between HIV infection and bone health. This review explores the multifactorial nature of HIV-associated bone disease, encompassing the effects of the virus itself, antiretroviral therapy, chronic inflammation, immune dysfunction and traditional risk factors for osteoporosis. Through an analysis of current research findings, potential mechanisms driving bone loss in HIV-infected individuals are elucidated, along with emerging therapeutic strategies aimed at mitigating skeletal complications. Understanding the complexities of HIV-associated bone disease is crucial for optimizing clinical management and enhancing the quality of life for affected individuals.