Química medicinal

Biochemical and Hormones Study on Diabetic Nephrotic Patients

Abstract

Ahmed Sulaiman Jumaa, Firas Taher Maher and Hanaa Ka’an Salah

Background: Diabetes mellitus is a growing epidemic and is the most common cause of chronic kidney disease (CKD) and kidney failure. Diabetic nephropathy affects approximately 20–40% of individuals who have diabetes. Diabetic nephropathy can be detected by the measurement of urine albumin or serum creatinine. Visceral adipose tissue-derived serine proteinase inhibitor (vaspin) was identified in the visceral adipose tissue of OLETF (Otsuka Long-Evans Tokushim a Fatty) rats, an animal model of obesity and type 2 diabetes mellitus (T2DM).

Material and methods: In this study conducted on 70 individuals in the age group of 35-70 years, from Kirkuk General Hospital. study group consists 40 individuals with diabetic nephropathy and 30 ages and sex matched healthy individuals (control).

Reasults: Serum vaspin of diabetic nephropathy patients showed a high significant relationship (p<0.0001). as compared with the controls. There is high significant decrease (p<0.001) in the serum levels of T4 and T3. There is high significant increase (p<0.001) in the serum levels of TSH as compared with the controls. There is high significant increase (p<0.001) in the serum concentration of K+ and uric acid and glucose as compared with the controls. There is high significant decrease (p<0.001) in the serum levels of Ca++ and Na+ as compared with the controls. There is high significant increase (p<0.001) in the serum levels of Cholesterol, TG, LDL and VLDL as compared with the controls. There is significant decrease (p<0.05) in the serum levels of HDL as compared with the controls.

Conclusion: The hormones (vaspin, TSH, T4, T3) have higher diagnostic validity values in the current study, which may be useful as a diagnostic tool to identify recurrence of the diabetic nephropathy syndromes.