Química medicinal

Antidiabetic and Antioxidant Effects of Newly Synthesized Pyrimido[1,6-a] Pyrimidine Derivatives in Neonatal Streptozotocin-Induced Diabetic Rats

Abstract

Osama Mohamed Ahmed, Ahmed M. Hussein and Rasha Rashad Ahmed

Synthesis of some novel pyrimido[1,6-a]pyrimidine derivatives 4, 8 and 10 was described through the respective reactions of sodium salts of formyl ketones 1, 7 and 9 with 6-aminothiouracil. The characterization of the reaction products was confirmed by using the available elemental analysis and spectral data. One of these derivatives (4b), 1-thioxo-1,2,7,8,9,10-hexahydro-3H-pyrimido[1,6-a]quinazolin-3-one, was tested using sublethal dose level (10 mg/kg b. w./day for 3 weeks) and was found to have potent antihyperglycemic, antihyperlipidemic and antioxidant properties in neonatal streptozotocin-induced (n-STZ) diabetic male and female albino rats.