Química medicinal

A Review on Different Synthetic Route and the Medicinal Aplications of 2-(3-(Dimethylamino)Propyl) Isoindoline-1,3-Dione Derivatives

Abstract

Rajesh Kumar Das*, and Sahin Reja

2-(3-(Dimethylamino)Propyl)Isoindoline-1,3-Dione (DAPID) derivatives have been obtained by the reaction of the phthalic acid anhydride derivatives with N, N dimethyl propyl amine derivatives. The yield of DAPID type derivative was 60% by classical way which was carried out in our laboratory. But when this reaction was carried out by modern way i.e. microwave enhance method, then the yield was 85% to 91% with short time. 3-(1,3-dioxoisoindolin-2-yl)-N,N-dimethylpropan-1-ammonium perchlorate (DIDAP) derivatives have been obtained by the reaction of 2-(3-(Dimethylamino)Propyl)Isoindoline-1,3-Dione (DAPID) derivatives with salt. The DIDAP compound was synthesized in a different route followed by able to show it’s excellent anticancer activity against hepatomas Hep G2 Cell line.